Dual selective iron chelating probes with a potential to monitor mitochondrial labile iron pools.
نویسندگان
چکیده
Mitochondria-targeted peptides incorporating dual fluorescent and selective iron chelators have been designed as novel biosensors for the mitochondrial labile iron pool. The probes were demonstrated to specifically co-localize with mitochondria and their fluorescence emission was found to be sensitive to the presence of iron.
منابع مشابه
Microsoft Word - bj20150149
Mitochondrial labile iron (LI) plays a crucial role in oxidative injuries and pathologies. At present, there is no organelle-specific sensitive iron sensor which can reside exclusively in the mitochondria and reliably monitor levels of LI in this organelle. Here we describe the development of novel fluorescent and highly specific mitochondria iron sensors, using the family of mitochondrial-homi...
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عنوان ژورنال:
- Chemical communications
دوره 52 4 شماره
صفحات -
تاریخ انتشار 2016